P Ethoxyacetanilide Medicine Raw Material For Relieving Fever /
Reducing Drug CAS 62-44-2
Phenacetin, ( Phenacetin, or acetophenetidin ), chemical formula
C10H13NO2, is a white crystalline solid at room temperature,
melting point 134 ℃, is a by many countries to ban drugs.
Phenacidine is a white, shiny flake crystal or white crystalline
powder. The melting point of 137-138 ℃, the refractive index of
1.571. Insoluble in water, slightly soluble in ether, slightly
soluble in boiling water, dissolved in ethanol and chloroform. When
dissolved in concentrated sulfuric acid, it does not show color,
and when it drops into the solution, it is orange. Odorless, bitter
Known mechanism of action
Its analgesic effects are due to its actions on the sensory tracts
of the spinal cord. In addition, phenacetin has a depressant action
on the heart, where it acts as a negative inotrope. It is an
antipyretic, acting on the brain to decrease the temperature set
point. It is also used to treat rheumatoid arthritis ( subacute
type ) and intercostal neuralgia.
It is metabolized in the body as paracetamol ( acetaminophen ),
which is also a clinically relevant analgesic.
Phenacetin was widely used until the third quarter of the twentieth
century, often in the form of an "A.P.C." or aspirin - phenacetin -
caffeine compound analgesic, as a remedy for fever and pain. An
early formulation ( 1919 ) was Vincent's APC in Australia. However
the U.S. Food and Drug Administration ordered the withdrawal of
drugs containing phenacetin in November 1983, owing to its
carcinogenic and kidney - damaging properties ( Federal Register of
October 5, 1983 ( 48 FR 45466 ) ). It was also banned in India. As
a result, some branded, previously phenacetin - based preparations
continued to be sold, but with the phenacetin replaced by safer
A popular brand of phenacetin was Roche's Saridon, which was
reformulated in 1983 to contain propyphenazone, paracetamol and
caffeine. Coricidin was also reformulated without phenacetin.
Paracetamol is a metabolite of phenacetin with similar analgesic
and antipyretic effects, but the new formulation has not been found
to have phenacetin's carcinogenicity.
Phenacetin is now being used as a cutting agent to adulterate
cocaine in the UK and Canada, owing to the similar physical
features of the two drugs.
Due to low - cost phenacetin is used for research into the physical
and refractive properties of crystals. It is an ideal compound for
this type of research.
1. Disable the allergy of this product, pregnant woman and
2. Disables of liver and kidney function;
3. Patients with hemolytic disease or other blood disease history
4. Old people and children should be careful.
Items of analysis
Should comply with the standard
134ºC to 136.5ºC
134.5ºC to 136.5ºC
through a uss#80