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P Ethoxyacetanilide Medicine Raw Material For Relieving Fever / Reducing Drug

P Ethoxyacetanilide Medicine Raw Material For Relieving Fever / Reducing Drug

Brand Name : PooChun
Model Number : CAS 62-44-2
Certification : ISO9001 SGS HACCP
Place of Origin : China
MOQ : Negotiable
Price : Negotiable
Payment Terms : T/T, L/C, Western Union, MoneyGram
Supply Ability : 100 ton per Month
Delivery Time : 1-3days after payment
Packaging Details : 1~10 kg / Al-Pt bag,10kg / 25kg fiber drum
CAS : 62-44-2
Appearance : White powder
Usage : Neuralgia
Type : pain-relieving fever - reducing drug
Payment terms : T/T, Western Union, Paypal, Moneygram
Trade terms : FOB CNF CIF DAP DDU
Shipping : DHL TNT FedEx HKEMS UPS
MW : 179.216
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P Ethoxyacetanilide Medicine Raw Material For Relieving Fever / Reducing Drug CAS 62-44-2



Description


Phenacetin, ( Phenacetin, or acetophenetidin ), chemical formula C10H13NO2, is a white crystalline solid at room temperature, melting point 134 ℃, is a by many countries to ban drugs. Phenacidine is a white, shiny flake crystal or white crystalline powder. The melting point of 137-138 ℃, the refractive index of 1.571. Insoluble in water, slightly soluble in ether, slightly soluble in boiling water, dissolved in ethanol and chloroform. When dissolved in concentrated sulfuric acid, it does not show color, and when it drops into the solution, it is orange. Odorless, bitter taste.


Known mechanism of action


Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis ( subacute type ) and intercostal neuralgia.

It is metabolized in the body as paracetamol ( acetaminophen ), which is also a clinically relevant analgesic.


Use


Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin - phenacetin - caffeine compound analgesic, as a remedy for fever and pain. An early formulation ( 1919 ) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney - damaging properties ( Federal Register of October 5, 1983 ( 48 FR 45466 ) ). It was also banned in India. As a result, some branded, previously phenacetin - based preparations continued to be sold, but with the phenacetin replaced by safer alternatives.


A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.


Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.


Due to low - cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.


Contraindication


1. Disable the allergy of this product, pregnant woman and lactation;

2. Disables of liver and kidney function;

3. Patients with hemolytic disease or other blood disease history are disabled;

4. Old people and children should be careful.


Product name


Phenacetin


CAS No.

62-44-2


Outer Packing

25KG


Production date

2016.05.07


Shelf life
2019.05.05


Standard adopted


BP68


Items of analysis


Specification


Results


Description


Should comply with the standard


Comforms


Identification


Positive


Positive


Melting point


134ºC to 136.5ºC


134.5ºC to 136.5ºC


4-chloroacetanilide


BP1968


<3.5ml/0.6g


P-Phenetidine


BP1968


Comforms


Sulphated ash


≤0.1%


0.07%


Assay


≥99%


99.1%

80
through a uss#80



98%


Conclusion


Qualified


Product Tags:

pharmaceutical intermediates

      

pharmaceutical raw materials

      
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