Tadalafil Medicine Raw Material For pulmonary arterial hypertension
PDE5 Inhibitor C22H19N3O4
Tadalafil is cyclic guanosine phosphate ( cGMP ) specific
phosphodiesterase 5 ( PDE5 ) selectivity and reversible inhibitor,
when sexual stimulation leads to partial release nitric oxide,
tadalafil inhibit PDE5, make the penis sponge body cGMP level,
resulting in smooth muscle relaxation, blood flow to the penis,
produce an erection, such as asexual stimulation.
Selectivity compared with other PDE5 inhibitors
Tadalafil, sildenafil, and vardenafil all act by inhibiting the
PDE5 enzyme. These drugs also inhibit other PDE enzymes. Sildenafil
and vardenafil inhibit PDE6, an enzyme found in the eye, more than
tadalafil. Some sildenafil users see a bluish tinge and have a
heightened sensitivity to light because of PDE6 inhibition.
Sildenafil and vardenafil also inhibit PDE1 more than tadalafil.
PDE1 is found in the brain, heart, and vascular smooth muscle. It
is thought that the inhibition of PDE1 by sildenafil and vardenafil
leads to vasodilation, flushing, and tachycardia. Tadalafil
inhibits PDE11 more than sildenafil or vardenafil. PDE11 is
expressed in skeletal muscle, the prostate, the liver, the kidney,
the pituitary gland, and the testes. The effects on the body of
inhibiting PDE11 are not known.
1. Like its predecessor Viagra, Cialis is used to treat erectile
dysfunction in men.
2. One of the more embarrassing side effects of post - cycle -
therapy is the decreased libido caused by the sudden absence of
exaggerated testosterone levels in the body, often leading to ED.
If you cann't get it up after your cycle, get the pill.
3. Tadalafil is the raw material of cialis.
4. Cialis is a kind of male sex enhancer drug.
5. Cialis is much longer lasting than Viagra. Effects can be felt
anywhere between 36-48 hours.
6. Cialis works by aiding relaxation of blood vessels and
increasing blood flow in the penis during sexual arousal, resulting
in improved erectile function
|Test Items||Specification||Test Results|
|Test method||High pressure liquid chromatography(HPLC)||Conforms|
|Loss on drying||≤0.5%||0.24%|
|Residue on ignition||≤0.1%||0.08%|
|Assay (on dried basis)||≥98.5%||99.53%|
|Conclusion||The product conform to USP 32|
Tadalafil is an annulated 2,5- diketopiperazine. It is also a
1,2,3,4- tetrahydro - β - carboline.
Tadalafil can be synthesized starting from ( D ) - tryptophan
methyl ester and piperonal via a Pictet – Spengler reaction. This
is followed by condensations with chloroacetyl chloride and
methylamine to complete the diketopiperazine ring: