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CAS 171596-29-5 Sex Powder Tadalafil , Male Enhancement Drugs Tadalafil Powder

CAS 171596-29-5 Sex Powder Tadalafil , Male Enhancement Drugs Tadalafil Powder

Brand Name : PooChun
Model Number : CAS 171596-29-5
Certification : ISO9001 SGS HACCP
Place of Origin : China
MOQ : Negotiable
Price : Negotiable
Payment Terms : T/T, L/C, Western Union, MoneyGram
Supply Ability : 100 ton per Month
Delivery Time : 1-3days after payment
Packaging Details : 1~10 kg / Al-Pt bag,10kg / 25kg fiber drum
CAS : 171596-29-5
Appearance : White powder
Usage : treat erectile dysfunction in men
Type : male sex enhancer drug
Payment terms : T/T, Western Union, Paypal, Moneygram
Trade terms : FOB CNF CIF DAP DDU
Shipping : DHL TNT FedEx HKEMS UPS
MW : 389.404
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Tadalafil Medicine Raw Material For pulmonary arterial hypertension PDE5 Inhibitor C22H19N3O4


Description


Tadalafil is cyclic guanosine phosphate ( cGMP ) specific phosphodiesterase 5 ( PDE5 ) selectivity and reversible inhibitor, when sexual stimulation leads to partial release nitric oxide, tadalafil inhibit PDE5, make the penis sponge body cGMP level, resulting in smooth muscle relaxation, blood flow to the penis, produce an erection, such as asexual stimulation.


Selectivity compared with other PDE5 inhibitors


Tadalafil, sildenafil, and vardenafil all act by inhibiting the PDE5 enzyme. These drugs also inhibit other PDE enzymes. Sildenafil and vardenafil inhibit PDE6, an enzyme found in the eye, more than tadalafil. Some sildenafil users see a bluish tinge and have a heightened sensitivity to light because of PDE6 inhibition. Sildenafil and vardenafil also inhibit PDE1 more than tadalafil. PDE1 is found in the brain, heart, and vascular smooth muscle. It is thought that the inhibition of PDE1 by sildenafil and vardenafil leads to vasodilation, flushing, and tachycardia. Tadalafil inhibits PDE11 more than sildenafil or vardenafil. PDE11 is expressed in skeletal muscle, the prostate, the liver, the kidney, the pituitary gland, and the testes. The effects on the body of inhibiting PDE11 are not known.


Applications


1. Like its predecessor Viagra, Cialis is used to treat erectile dysfunction in men.

2. One of the more embarrassing side effects of post - cycle - therapy is the decreased libido caused by the sudden absence of exaggerated testosterone levels in the body, often leading to ED. If you cann't get it up after your cycle, get the pill.

3. Tadalafil is the raw material of cialis.

4. Cialis is a kind of male sex enhancer drug.

5. Cialis is much longer lasting than Viagra. Effects can be felt anywhere between 36-48 hours.

6. Cialis works by aiding relaxation of blood vessels and increasing blood flow in the penis during sexual arousal, resulting in improved erectile function


Specification


Test ItemsSpecificationTest Results
AppearanceWhite powderConforms
Test methodHigh pressure liquid chromatography(HPLC)Conforms
Melting Point300℃~303℃301.5℃-302.6℃
Loss on drying≤0.5%0.24%
Heavy metals(Pb)≤20ppm7.5ppm
Residue on ignition≤0.1%0.08%
Relative substance≤1.0%0.145%
Assay (on dried basis)≥98.5%99.53%
ConclusionThe product conform to USP 32

Chemistry


Tadalafil is an annulated 2,5- diketopiperazine. It is also a 1,2,3,4- tetrahydro - β - carboline.

Tadalafil can be synthesized starting from ( D ) - tryptophan methyl ester and piperonal via a Pictet – Spengler reaction. This is followed by condensations with chloroacetyl chloride and methylamine to complete the diketopiperazine ring:


Tadalafil synthesis



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steroid hormones

      

pharmaceutical intermediates

      
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CAS 171596-29-5 Sex Powder Tadalafil , Male Enhancement Drugs Tadalafil Powder Images

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